Соматические симптомы депрессии
Психические расстройства в общей медицине. №4 2007
Соматические симптомы депрессии
H.-P.Kapfhammer
Германия
Стр. 53-61
3334 просмотров
Опубликовано: 1 апреля 2007
Аннотация / Abstract
История концепций депрессии
В феноменологической психопатологии традиционно акцентируется внимание на телесных проявлениях депрессивных расстройств как на их ключевых симптомах. Так, C.Wernicke использовал термин “витальные чувства” для описания определенных соматических симптомов, возникающих при аффективных психозах [1]. Витальные чувства касаются тесной взаимосвязи телесности и самосознания, того, как мы ощущаем собственное тело и какое впечатление производит на окружающих наш внешний вид. Витальные чувства представляют собой соматический аффект, происходящий из различных частей тела. Если в норме витальные чувства формируют общий фон телесного самоощущения, то при депрессии они могут выступать на первый план. Например, страдающие депрессией часто жалуются на необычные головные боли, описываемые как непереносимое давление, сравнимое с повязкой, стягивающей голову. Другие нарушения витальных чувств затрагивают грудную клетку и область живота, вызывая неприятные ощущения тяжести, напряжения или заторможенности, на которых концентрируется внимание пациента. Аналогичным образом E.DuprО говорит о коэнестопатических состояниях, представляющих собой тягостные качественные изменения нормального телесного чувства в различных частях тела при эпизодах депрессии. При этом происходит тотальная потеря витальности, при которой нарушения могут охватывать тело и его функции целиком, подавляя нормальную жизнедеятельность [2]. K.Schneider [3] относил подобные расстройства витальных чувств к числу признаков, определяющих картину эндогенной депрессии. В психопатологической квалификации автора проявления депрессивной болезни обладают первостепенной диагностической значимостью, аналогичной симптомам первого ранга при шизофрении. G. Huber проводил различие между витальными расстройствами, с одной стороны, и вегетативными симптомами депрессии – с другой [4]. Витальные расстройства (потеря общего телесного тонуса, доминирование усталости/утомляемости, а также раз...
История концепций депрессии
В феноменологической психопатологии традиционно акцентируется внимание на телесных проявлениях депрессивных расстройств как на их ключевых симптомах. Так, C.Wernicke использовал термин “витальные чувства” для описания определенных соматических симптомов, возникающих при аффективных психозах [1]. Витальные чувства касаются тесной взаимосвязи телесности и самосознания, того, как мы ощущаем собственное тело и какое впечатление производит на окружающих наш внешний вид. Витальные чувства представляют собой соматический аффект, происходящий из различных частей тела. Если в норме витальные чувства формируют общий фон телесного самоощущения, то при депрессии они могут выступать на первый план. Например, страдающие депрессией часто жалуются на необычные головные боли, описыв...
Материал для специалистов
Полный текст статьи доступен только зарегистрированным пользователям.
Вход / Регистрация- 1. Wernicke C. Grundlagen der Psychiatrie. Leipzig, Germany: Thieme, 1906.
- 2. Dupre E. Les cenestopathies. (transl. Rohde M). In: Hirsch SR, Shepherd M, eds. Themes and Variations in European Psychiatry. Bristol, UK: John Wright, 1974.
- 3. Schneider K. Die Schichtung des emotionalen Lebens und der Aufbau der Depressionszustande. Z Oes Neurol Psychiatr 1920; 59: 281–6.
- 4. Huber G. Psychiatrie. Lehrbuch fur Studium und Weiterbildung. 7th ed. Stuttgart, Germany: Schattauer, 2005.
- 5. Bleuler M. Die Depressionen in der Allgemeinpraxis. 2nd ed. Basel, Switzerland: Schwabe, 1943; 10–11.
- 6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Text Revision. Washington, DC: American Psychiatric Press, 2003.
- 7. Tylee A, Gandhi P. The importance of somatic symptoms in depression in primary care. Prim Care Companion J Clin Psychiat 2005; 7: 167–76.
- 8. Maier W, Falkai P. The epidemiology of comorbidity between depression, anxiety disorders and somatic diseases. Int Clin Psychopharmacol 1999; 14 (suppl. 2): 1–6.
- 9. Kapfhammer HP. Die psychopharmakologische Behandlung von angstlich-depressiven Syndromen im Kontext somatischer Erkrankungen. In: Moller HJ,
- ed. Therapie psychiatrischer Erkrankungen. 3rd ed. Stuttgart, Germany: Thieme, 2005.
- 10. Kapfhammer HP. Behandlung von somatoformen Storungen. In: Moller HJ, ed. Therapie psychiatrischer Erkrankungen. 3rd ed. Stuttgart, Germany: Thieme, 2005.
- 11. Kroenke K. Somatic symptoms and depression: a double hurt. Prim Care Companion J Clin Psychiat 2005; 7: 148–9.
- 12. Hamilton M. Frequency of symptoms in melancholia (depressive illness). Br J Psychiat 1989; 154: 201–6.
- 13. Akiskal HS. Diagnosis and classification of affective disorders: new insights from clinical and laboratory approaches. Psychiat Dev 1983; 2: 123–60.
- 14. Jones D, Hall SB. Significance of somatic complaints in depression in patients suffering from psychotic depression. Acta Psychotherapeutic 1963; 11: 193–9.
- 15. Hagnell O, Rorsman B. Suicide and endogenous depression with somatic symptoms in the lundby study. Neuropsychobiology 1978; 4: 180–7.
- 16. ESEMeD/MHEDEA 2000 Investigators. Disability and quality of life impact of mental disorders in Europe: Results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiat Scand 2004; 109 (suppl. 1): 47–54.
- 17. Katon WJ, Unutzer J, Simon G. Treatment of depression in primary care. Where we are, where we can go. Med Care 2004; 42: 1153–7.
- 18. Lepine JP, Gastpar M, Mendlewitz J, Tyee A, on behalf of the DEPRES Steering Committee Depression in the community (Depression Research in European Society). Int Clin Psychopharmacol 1997; 12: 19–29.
- 19. Wittchen HU, Hofler M, Meister W. Depressionen in der Allgemeinpraxis. Die bundesweite Depressionsstudie. Stuttgart, Germany: Schattauer, 2000.
- 20. Paykel ES, Brugha T, Fryers T. Size and burden of depressive disorders in Europe. Eur Neuropsychopharmacol 2005; 15: 411–23.
- 21. Kirmayer LJ, Groleau D, Looper KJ, Dao MD. Explaining medically unexplained symptoms. Can J Psychiat 2004; 49: 663–72.
- 22. Kroenke K. The interface between physical and psychological symptoms. Prim Care Companion J Clin Psychiatry 2003; 5: 11–8.
- 23. Tylee A, Gastpar M, Lepine JP et al. DEPRES II (Depression research in European society II): a patient survey of the symptoms, disability, and current management of depression in the community. DEPRES Steering Commitee. Int Clin Psychopharmacol 1999; 14: 139–51.
- 24. Simon G.E, Korff von M, Piccinelli M et al. An international study of the relation between somatic symptoms and depression. N Engl J Med 1999; 341: 1329–35.
- 25. Kirmayer LJ, Robbins JM, Dworking M et al. Somatisation and the recognition of depression and anxiety in primary care. Am J Psychiat 1993; 150: 734–41.
- 26. Bair MJ, Robinson RL, Katon W et al. Depression and pain comorbidity: a literature review. Arch Intern Med 2003; 163: 2433–45.
- 27. Khan AA, Khan A, Harezlak J et al. Somatic symptoms in primary care: etiology and outcome. Psychosomatics 2003; 44: 471–8.
- 28. Kroenke K, Mangelsdorff AD. Common symptoms in ambulatory care: incidence, evaluation, therapy, and outcome. Am J Med 1989; 86: 262–6.
- 29. Kroenke K. Patients presenting with somatic complaints: epidemiology, psychiatric comorbidity, and management. Int J Methods Psychiatr Res 2003; 12: 34–43.
- 30. Kisely S, Goldberg D, Simon G. A comparison between somatic symptoms with and without clear organic cause: results of an international study. Psychol Med 1997; 27: 1011–9.
- 31. Kroenke K, Spitzer RL, Williams JBW et al. Physical symptoms in primary care: predictors of psychiatric disorders and functional impairment. Arch Earn Med 1994; 3: 774–9.
- 32. Reid S, Wessely S, Crayford T et al. Medically unexplained symptoms in frequent attenders of secondary health care: retrospective cohort study. BMJ 2001; 322: 767.
- 33. Spitzer RL, Kroenke K, Williams JBW. Validation and utility of a selfre-port version of PRIME-MD: the PHQ primary care study. JAMA 1999; 282: 1737–44.
- 34. Gerber PD, Barrett JE, Barrett JA et al. The relationship of presenting physical complaints to depressive symptoms in primary care patients. J Gen Intern Med 1992; 7: 170–3.
- 35. Aaron LA, Buchwald D. A review of the evidence for overlap among unexplained clinical conditions. Ann Intern Med 2001; 134: 868–81.
- 36. Wesseley S, White PD. There is only one functional somatic syndrome. Br J Psychiat 2004; 185: 95–6.
- 37. Manu P, ed. Functional Somatic Syndromes. Etiology, Diagnosis and Treatment. Cambridge, UK: Cambridge University Press, 1988; 32–57.
- 38. Deary IJ. A taxonomy of medically unexplained symptoms. J Psychosom Res 1999; 47: 51–9.
- 39. Henningsen P, Zimmermann T, Sattel H. Medically unexplained physical symptoms, anxiety and depression: a meta-analytic review. Psychosom Med 2003; 65: 528–33.
- 40. Hudson Jl, Mangweth B, Pope HG et al. Family study of affective spectrum disorder. Arch Gen Psychiat 2003; 60: 170–7.
- 41. Robbins JM, Kirmayer LJ, Hemami S. Latent variable models of functional somatic distress. J Nerv Ment Dis 1997; 22: 551–64.
- 42. Gureje O, Simon G. E, Von Korff M. A cross-national study of the course of persistent pain in primary care. Pain 2001; 92: 195–200.
- 43. Lepine JP, Briley M. The epidemiology of pain in depression. Hum Psychopharmacol Clin Exp 2004; 19: 3–7.
- 44. Wells KB, Stewart A, Hays RD et al. The functioning and well-being of depressed patients: results from the Medical Outcomes Study. JAMA 1989; 262: 914–9.
- 45. Kessler RC, McGonagle KA, Zhao S et al. Lifetime and 12-month prevalence of DSM-lll-psychiatric disorders in the United States: Results from the National Comorbidity Survey. Arch Gen Psychiat. 1994; 51: 8–19.
- 46. Regier DA, Myers JK, Kramer M et al. The NIMH Epidemiologic Catchment Area program: historical context, major objectives, and study population characteristics. Arch Gen Psychiat 1984; 41: 934–41.
- 47. Kroenke K, Price RK. Symptoms in the community: prevalence, classification, and psychiatric comorbidity. Arch Intern Med 1993; 153: 2474–80.
- 48. Magni G, Marchetti M, Moreschi C et al. Chronic musculoskeletal pain and depressive symptoms in the National Health and Nutrition Examination, I: epidemiologic follow-up study. Pain 1993; 53: 163–8.
- 49. Ohayon MM, Schatzberg AF. Using chronic pain to predict depressive morbidity in the general population. Arch Gen Psychiat 2003; 60: 39–47.
- 50. Katon W. Diagnosis: relationship to somatization and chronic medical illness. J Clin Psychiat 1984; 45: 4–12.
- 51. De Waal MWM, Arnold IA, Eekhof AJH, Van Hemert AM. Somatoform disorders in general practice. Br J Psychiatr 2004; 184: 470–6.
- 52. De Waal MWM, Arnold IA, Spinhoven P et al. The reporting of specific physical symptoms for mental distress in general practice. J Psychosom Res 2005; 59: 89–95.
- 53. Dickinson WP, Dickinson ML, deGruy FV et al. The somatization in primary care study: a tale of three diagnoses. Gen Hosp Psychiat 2003; 25: 1–7.
- 54. Haug TT, Mykletun A, Dahl AA. The association between anxiety, depression, and somatic symptoms in a large population: the HUNT-II study. Psychosom Med 2004; 66 (suppl. 6): 845–51.
- 55. Jacobi F, Wittchen HU, Holting C et al. Prevalence, comorbidity and correlates of mental disorders in the general population: Results from the German Health Interview and Examination Survey (GHS). Psychol Med 2004; 34: 597–611.
- 56. Maier W. Angst- und Somatisierungsstorungen. Fortschr Neurol Psychiat 1998; 66 (suppl. 1): 3–8.
- 57. Peveler R, Kilkenny L, Kinmonth AL. Medically unexplained phys^al symptoms in primary care: a comparison of selfreport screening questionnaires and clinical opinion. J Psychosom Res 1997; 42: 245–52.
- 58. Smith RC, Gardiner JC, Lyles JS et al. Exploration of DSM-IV criteria in primary care patients with medically unexplained symptoms. Psychosom Med 2005; 67: 123–9.
- 59. Kroenke K, Jackson J.L, Chamberlin J. Depressive and anxiety disorders in patients presenting with physical complaints: clinical predictors and outcome. Am J Med 1997; 103: 339–47.
- 60. Katon W, Lin E, Von Korff M et al. Somatization: a spectrum of severity. Am J Psychiat 1991; 148: 34–40.
- 61. Katon W, Sullivan M, Walker E. Medical symptoms without identified pathology: relationship to psychiatric disorder, childhood and adult trauma, and personality traits. Ann Intern Med 2001; 134: 917–25.
- 62. Moller HJ, Demyttenaere K, Sacchetti E et al. Improving the chance of recovery from the short- and long-term consequences of depression. Int Clin Psychopharmacol 2003; 18: 221–5.
- 63. Yates WR, Mitchel J, Rush AJ et al. Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D. Gen Hosp Psychiat 2004; 26 (suppl. 6): 421–9.
- 64. Susser M. Disease, illness, sickness: impairment, disability and handicap. Psychol Med 1990; 20: 471–3.
- 65. Simon G, von Korff M. Medical co-morbidity and validity of DSM-IV depression criteria. Psychol Med 2005; 35: 1–10.
- 66. Wilhelm K, Kotze B, Waterhouse M et al. Screening for depression in the medically ill: a comparison of self-report measures, clinician judgement, and DSM-IV diagnoses. Psychosomatics 2004; 45: 461–9.
- 67. Yates WR. Epidemiology of psychiatric disorders in the medically ill. In: Robinson RG, Yates WR, eds. Psychiatric Treatment of the Medically III. New York, NY; Basel, Switzerland: Marcel Dekker, 1999; 41–64.
- 68. Fryers T. Melzer D, Jenkins R. Social inequalities and the common mental disorders. A systematic review of the evidence. Soc Psychiatry Psychiatr Epidemiol 2003; 38: 229–37.
- 69. Weich S, Lewis G, Donmall R, Mann A. Somatic presentation of psychiatric morbidity in general practice. Br J Gen Pract 1995; 45: 143–7.
- 70. Nuyen J, Vokers AC, Verhaak PFM et al. Accuracy of diagnosing depression in primary care: the impact of chronic somatic and psychiatric co-morbidity. Psychol Med 2005; 35: 1185–95.
- 71. Drayer RA, Mulsant BH, Lenze EJ et al. Somatic symptoms of depression in elderly patients with medical comorbidities. Int J Geriatr Psychiat 2005; 20: 973–82.
- 72. Bridges KW, Goldberg DP. Somatic presentation of DSM III psychiatric disorder in primary care. J Psychosom Res 1985; 29: 563–9.
- 73. Schuyler D. Depression comes in many disguises to the providers of primary care: recognition and management. J S C Med Assoc 2000; 96: 267–75.
- 74. Kessler D, Bennewith O, Lewis G et al. Detection of depression and anxiety in primary care: follow up study. BMJ 2002; 325: 1016–7.
- 75. Kirmayer U. Robbins JM. Patients who somatize in primary care: a longitudinal study of cognitive and social characteristics. Psychol Med 1996; 26: 937–57.
- 76. Barkow K, Heun R, Ustun TB et al. Identification of items which predict later development of depression in primary health care. Eur Arch Psychiatry Clin Neurosci 2001; 25 (suppl. 2): 21–6.
- 77. Berardi D, Menchetti M, Cervenini N et al. Increased recognition of depression in primary casre. Comparison between primary-care physician and ICD-10 diagnosis of depression. Psychother Psychosom 2005; 74: 225–30.
- 78. Henkel V, Mergl R, Coyne JC et al. Depression with atypical features in a sample of primary care outpatients: Prevalence, specific characteristics and consequences. J Affect Disord 2004; 83: 237–42.
- 79. Wittchen HU, Pittrow D. Prevalence, recognition and management of depression in primary care in Germany: the Depression 2000 study. Hum Psychopharmacol Clin Exp 2002; 17: S1–11.
- 80. Kirmayer LJ, Robbins JM. Three forms of somatization in primary care: prevalence, co-occurrence, and sociodemographic characteristics. J Nerv Ment Dis 1991; 179: 645–55.
- 81. Linden M, MaierW, Achberger M et al. Psychische Erkrankungen und ihre Behandlung in Allgemeinpraxen in Deutschland. Nervenarzt. 1996; 67: 205–15.
- 82. Lloyd GG. Psychiatric syndromes with a somatic presentation. J Psychosom Res 1986; 30: 113–20.
- 83. Kapfhammer HP. Geschlechtsdifferenzielle Perspektive auf somatoforme Storungen. Psychiatrie & Psychotherapie. 2005; 1: 21–32.
- 84. Silverstein B. Gender difference in the prevalence of clinical depression: the role played by depression associated with somatic symptoms. Am J Psychiat 1999; 156: 480–2.
- 85. Silverstein B. Gender differences in the prevalence of somatic versus pure depression: a replication. Am J Psychiat 2002; 159: 1051–2.
- 86. Wenzel A, Steer RA, Beck AT. Are there any gender differences in frequency of self-reported somatic symptoms of depression? J Affect Disord 2005; 89: 177–81.
- 87. Kroenke K, Spitzer R. Gender differences in the reporting of physical and somatoform symptoms. Psychosom Med 1998; 60: 150–5.
- 88. Jackson JL, Chamberlin J, Kroenke K. Gender and symptoms in primary care practices. Psychosomatics 2003; 44: 359–66.
- 89. Sandanger I, Nygard J.F, Sorensen T, Mourn T. Is women\'s mental health more susceptible than men\'s to the influence of surrounding stress. Soc Psychiatry Psychiatr Epidemiol 2004; 39: 177–84.
- 90. Stahl SM. Antidepressants and somatic symptoms: therapeutic actions are expanding beyond affective spectrum disorders to functional somatic syndromes. J Clin Psychiat 2003; 64: 7.
- 91. Craig TKJ, Boardman AP, Mills K et al. The South London somatization study I: Longitudinal course and the influence of early life experiences. Br J Psychiat 1993; 163: 570–88.
- 92. Rief W, Martin A, Klaiberg A, Brahler E. Specific effects of depression, panic and somatic symptoms on illness behavior. Psychosom Med 2005; 67: 596–601.
- 93. Henningsen P, Jakobsen T, Schiltenwolf M, Weiss MG. Somatization revisited diagnosis and perceived causes of common mental disorders. J Nerv Mental Dis 2005; 193: 85–92.
- 94. Rief W, Nake A, Emmerich J, Bender A, Zecht T. Causal illness attributions in somatoform disorders: associations with comorbidity and illness behavior. J Psychosom Res 2004; 57 (suppl. 4): 367–71.
- 95. Sayar K, Kirmayer LJ, Taillefer SS. Predictors of somatic symptoms in depressive disorder. Gen Hosp Psychiat 2003; 25: 108–14.
- 96. Rief W, Hiller W, Geissner E, Fichter MM. A two-year follow-up study of patients with somatoform disorders. Psychosomatics 1995; 36: 376–86.
- 97. Alper K, Devinsky O, Vasquez B et al. Non-epileptic seizures and childhood sexual and physical abuse. Neurology 1993; 43: 1950–3.
- 98. Kapfhammer HP, Rothenhausler HB. Malingering/Munchhausen: Factitious and somatoform disorders in neurology and clinical medicine. In: Hallett M, Fahn S, Jankovic J, Lang AE, Clonnger CR, Yudofsky SC, eds. Psychogenic Movement Disorders. Neurology and Neuropsychiatry. Philadelphia, Pa: Lippicott Williams & Wilkins; 2005; 154–62.
- 99. Coryell W, Norten SG. Briquet\'s syndrome (somatization disorder) and primary depression: comparison of background and outcome. Compr Psychiat 1981; 22: 249–56.
- 100. Drossman DA, Leserman J, Nachman G et al. Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 1990; 113: 828–33.
- 101. Golding JM. Sexual assault history and physical health in randomly selected Los Angeles women. Health Psychol 1994; 13: 130–8.
- 102. Morrison J. Childhood sexual histories of women with somatization disorder. Am J Psychiat 1989; 146: 239–41.
- 103. Walker EA, Katon WJ, Hansom J et al. Medical and psychiatric symptoms in women with childhood sexual abuse. Psychosom Med 1992; 54: 658–64.
- 104. Walker EA, Katon W, Harrop-Griffiths J et al. Relationship of chronic pelvic pain to psychiatric diagnoses and childhood sexual abuse. Am J Psychiat 1988; 145: 75–80.
- 105. Walker EA, Gelfand AN, Gelfand MD et al. Chronic pelvic pain and gynecological symptoms in women with irritable bowel syndrome. J Psychosom Obstet Gynecol 1996; 17: 39–46.
- 106. Walker EA, Gelfand A, Katon W et al. Adult health status of women with histories of childhood abuse and neglect. Am J Med 1999; 107: 332–9.
- 107. Barsky AJ, Wool C, Barnett MC et al. Histories of childhood trauma in adult hypochondriacal patients. Am J Psychiat 1994; 151: 397–401.
- 108. Kendler KS, Bulik CM, Silberg J et al. Childhood sexual abuse and adult psychiatric and substance disorders in women: An epidemiological and cotwin control analysis. Arch Gen Psychiat 2000; 57: 953–9.
- 109. Nelson EC, Heath AC, Madden PA et al. Associations between self-reported childhood sexual abuse and adverse psychosocial outcomes. Arch Gen Psychiat 2002; 59: 139–45.
- 110. Wise L, Zierler S, Krieger N et al. Adult onset of major depressive disorder in relation to childhood and adolescent violence victimization: a case-control study. Lancet 2001; 358: 881–7.
- 111. Arnow BA. Relationships between childhood maltreatment, adult health and psychiatric outcomes, and medical utilization. J Clin Psychiat 2004; 65 (suppl. 12): 10–5.
- 112. Stewart DE. Physical symptoms of depression: unmet need in special populations. J Clin Psychiat 2003; 64 (suppl. 7): 12–6.
- 113. Almeida Fleck de MP, Simon G, Herrman H et al. Major depression and its correlates in primary care settings in six countries. Br J Psychiat 2005; 186: 41–7.
- 114. Keller MB, Hirschfeld RMA, Demyttenaere K, Baldwin DS. Optimizing outcomes in depression: Focus on antidepressant compliance. Int Clin Psychopharmacol 2002; 17: 265–71.
- 115. Fava M. The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression. J Clin Psychiat 2003; 64 (suppl. 13): 26–9.
- 116. Judd LL, Akiskal HS, Maser JD et al. Major depressive disorder: a prospective study of residual subthreshold depressive symptoms as predictor of rapid relapse. J Affect Disord 1998; 50: 97–108.
- 117. Judd LL, Martin P, Schettler PJ et al. Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness. Am J Psychiat 2000; 157: 1501–4.
- 118. Paykel ES, Ramana R, Cooper Z et al. Residual symptoms after partial remission: an important outcome in depression. Psychol Med 1995; 25: 1171–80.
- 119. Kennedy N, Paykel ES. Residual symptoms at remission from depression: impact on long-term outcome. J Affect Disord 2004; 80: 135–44.
- 120. Fishbain DA. The relationship of chronic pain and suicide. Sem Clin Neuropsychiatry 1999; 4: 221–7.
- 121. Korff von M, Simon G. The relationship between pain and depression. Br J Psychiat 1996; 168: 101–8.
- 122. Bair MJ, Robinson RL, Eckert GJ et al. Impact of pain on depression treatment response in primary care. Psychosom Med 2004; 66: 17–22.
- 123. Karp JF, Scott J, Houck P et al. Pain predicts longer time to remission during treatment of recurrent depression. J Clin Psychiat 2005; 66 (suppl. 5): 591–7.
- 124. Simon Gregory E, Korff von M, Lin E. Clinical and functional outcomes of depression treatment in patients with and without chronic. Psychol Med 2005; 35: 271–9.
- 125. Bao Y, Sturm R, Croghan TW. A national study of the effect of chronic pain on the use of health care by depressed persons. Psychiatr Sen 2003; 54: 693–7.
- 126. Barsky AJ, Orav EJ, Bates DW. Somatization increases medical utilization and costs independent of psychiatric and medical comorbidity. Arch Gen Psychiat 2005; 62: 903–10.
- 127. Luber MP, Meyers BS, Williams-Russo PG et al. Depression and service utilization in elderly primary care patients. Am J Geriatr Psychiat 2001; 9: 169–76.
- 128. Keeley R, Smith M, Miller J. Somatoform symptoms and treatment non-adherence in depressed family medicine outpatients. Arch Fam Med 2000; 9: 46–54.
- 129. O\'Leary D, Paykel ES, Todd C, Vardulaki K. Suicide in primary affective disorders revisited: a systematic review by treatment era. J Clin Psychiat 2001; 62: 804–11.
- 130. Abbas M, Hotopf M, Prince M. Depression and mortality in a high-risk population: 1-year follow-up of the Medical Research Council Elderly Hypertension trial. Br J Psychiat 2000; 181: 123–8.
- 131. Angst F, Stassen HH, Clayton PJ et al. Mortality of patients with mood disorder: follow-up over 34-38 years. J Affect Disord 2002; 68: 167–81.
- 132. Penninx BWJH, Beekman ATF, Honig A et al. Depression and cardiac mortality: Results from a community-based longitudinal survey. Arch Gen Psychiat 2001; 58: 221–7.
- 133. Greden JF. Physical symptoms of depression: unmet needs. J Clin Psychiat 2003; 64 (suppl. 7): 5–11.
- 134. Greenberg PE, Leong SA, Birnbaum HG et al. The economic burden of depression with painful symptoms. J Clin Psychiat. 2003; 64 (suppl. 7): 17–23.
- 135. Fifer SK, Buesching DP, Henke CJ et al. Functional status and somatization as predictors of medical offset in anxious and depressed patients. Value Health 2003; 6: 40–50.
- 136. Doraiswamy PM, Khan ZM, Donahue RM et al. Quality of life in geriatric depression: a comparison of remitters, partial responders, and nonre-sponders. Am J Geriatr Psychiat 2001; 9: 423–8.
- 137. Nemeroff CB, Vale WW. The neurobiology of depression: inroads to treatment and new drug discovery. J Clin Psychiat 2005; 66 (suppl. 7): 5–13.
- 138. Stahl SM. The psychopharmacology of painful physical symptoms in depression. J Clin Psychiat 2002; 63: 5.
- 139. Demyttenaere K, De Fruyt J, Stahl SM. The many faces of fatigue in major depressive disorder. Int J Neuropsychopharmacol 2005; 8: 93–105.
- 140. Stahl SM, Briley M. Understanding pain in depression. Hum Psychopharmacol Clin Exp 2004; 19: 9–13.
- 141. Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Arch Gen Psychiat 1997; 54: 597–606.
- 142. Duman RS, Malberg J, Thome J. Neural plasticity to stress and antidepressant treatment. Biol Psychiat 1999; 46: 1181–91.
- 143. Dunn AJ, Swiergiel AH, de Beaurepaire R. Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Res 2005; 29: 891–909.
- 144. Flores BH, Musselman DL, DeBattista C et al. Biology of mood disorders. In: Schatzberg AF, Nemeroff CB, eds. The American Psychiatric Publishing Textbook of Psychopharmacology, 3rd ed. Washington, DC, London, UK: American Psychiatric Publishing, 2004; 717–63.
- 145. Gould E, Tanpat R, Rydel T et al. Regulation of hippocampal neurogenesis in adulthood. Biol Psychiat 1999; 48: 715–20.
- 146. Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006; 27: 24–31.
- 147. Ressler KJ. Pathophysiology of major depressive disorder. Monoamines, neuropeptides, and neurotrophins. Prim Care Companion J Clin Psychiat 2004; 6: 253–6.
- 148. Blackburn-Munro G. Hypothalamo-pituitary-adrenal axis dysfunction as a contributory factor to chronic pain and depression. Curr Pain Headache Reports 2004; 8: 116–24.
- 149. Blackburn-Munro G, Blackburn-Munro RE. Chronic pain, chronic stress and depression: coincidence or consequence. J Neuroendocrinol 2001; 13: 1009–23.
- 150. Blackburn-Munro G, Blackburn-Munro R. Pain in the brain: are hormones to blame? Trends Endocrinol Metab 2003; 14: 20–7.
- 151. Fava M. Somatic symptoms, depression and antidepressant treatment. J Clin Psychiat 2002; 63: 4.
- 152. Thase ME. Achieving remission and managing relapse in depression. Clin Psychiat 2003; 64 (suppl. 18): 3–7.
- 153. Fishbain DA. Relationship between physical symptoms and depression treatment response or resistence in patients with comorbid medical conditions. Prim Care Companion J Clin Psychiat 2005; 7: 288–90.
- 154. Lynch ME. Antidepressants as analgesics: a review of randomized controlled trials. J Psychiat Neurosci 2001; 26: 30–6.
- 155. Barkin RL, Barkin S. The role of venlafaxine and duloxetine in the treatment of depression with decremental changes in somatic symptoms of pain, chronic pain, and the pharmacokinetics and clinical considerations of duloxetine pharmacotherapy. Am J Therapeutics 2005; 12 (suppl. 5): 431–8.
- 156. Entsuah AR, Huang H, Thase ME. Response and remission rates in different subpopulations with major depressive disorder administered venlafaxine, selective serotonin reuptake inhibitors, or placebo. J Clin Psychiat 2001; 62: 869–77.
- 157. Smith D, Dempster C, Glanville J et al. Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: a meta-analysis. Br J Psychiat 2002; 180: 396–404.
- 158. Zajecka JM, Albano D. SNRIs in the management of acute major depressive disorder. J Clin Psychiat 2004; 65 (suppl. 17): 11–8.
- 159. Thase ME, Entsuah AR, Rudolph RL. Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors. Br J Psychiat 2001; 178: 234–41.
- 160. Brannan SK, Mallinckrodt CH, Brown EB et al. Duloxetine 60 mg once-daily in the treatment of painful physical symptoms in patients with major depressive disorder. J Psychiatr Res 2005; 39: 43–53.
- 161. Detke MJ, Wiltse CG, Mallinckrodt CH et al. Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paraxetine-controlled trial. Eur Neuropsych Pharmacol 2004; 14 (suppl. 6): 457–70.
- 162. Fava M, Mallinckrodt CH, Detke MJ et al. The effect of duloxetine on painful physical symptoms in depressed patients: do improvements in these symptoms result in higher remission rates. J Clin Psychiat 2004; 65 (suppl. 4): 521–30.
- 163. Goldstein DJ, Lu Y, Detke MJ et al. Effects of duloxetine on painful physical symptoms associated with depression. Psychosomatics 2004; 45: 17–28.
- 164. Vitton O, Gendreau M, Gendreau J et al. A double-blind, placebo-controlled trial of milnacipran in the treatment of fibromyalgia. Hum Psychopharmacol 2004; 19 (suppl. 1): S27–S37.
- 165. Schatzberg AF, Cole JO, DeBattista C. Manual of Clinical Psychopharmacology. 5th ed. Washington, DC, London, UK: American Psychiatric Publishing, 2005.
- 166. Fava M. Pharmacologic approaches to the management of residual symptoms in major depessive disorder. Prim Care Companion J Clin Psychiat 2004; 6: 256–8.
- 167. Hirschfeld RMA, Montgomery SA, Aguglia E et al. Partial response and nonresponse to antidepressant therapy: current approaches and treatment options. J Clin Psychiat 2002; 63: 826–37.
- 168. Fava GA, Ruini C, Sonnino N. Treatment of recurrent depression. A sequential psychotherapeutic and psychopharmacological approach. CNS Drugs. 2003; 17: 1109–17.
- 169. Thase ME. New approaches to severe and refractory depression. J Clin Psychiat 1999; 60: 629–30.