Депрессия и ревматоидный артрит: сочетание в ревматологической практике (обзор литературы)
Психические расстройства в общей медицине. №1 2010
Депрессия и ревматоидный артрит: сочетание в ревматологической практике (обзор литературы)
Е.А.Григорьева, Н.В.Яльцева, Н.И.Коршунов
Ярославская государственная медицинская академия
Стр. 45-47
2759 просмотров
Опубликовано: 1 февраля 2010
Аннотация / Abstract
Depression and rheumatoid arthritis, combination in rheumatoid practice (literature review)
E.A.Grigorieva, N.V.Yalceva, N.I.Korshunov
Yaroslavl state medical academy
Депрессия в ее различных клинических вариантах признается одной из основных причин снижения трудоспособности; по доле потерянных для полноценной жизни лет депрессивные расстройства в настоящее время опережают все прочие психические заболевания. К 2020 г. депрессии займут 2-е место среди всех заболеваний по интегративной оценке бремени, которое несет общество, уступая только ишемической болезни сердца. Особенно высока доля лиц, страдающих депрессиями, среди пациентов общесоматической сети [11, 52]. При этом как депрессия, так и хроническая боль у женщин встречаются в 2 раза чаще, чем у мужчин.
При исследовании распространенности хронической соматической патологии 62,5% населения имеют по крайней мере одно хроническое заболевание и артрит является одним из наиболее часто встречающихся [34, 63, 88]. Кроме того, артрит и депрессия – заболевания, имеющие самые низкие оценки качества жизни. Высокий уровень депрессии и тревоги был определен у пациентов с такими хроническими заболеваниями, как артрит и сахарный диабет типа 2, хроническая обструктивная болезнь легких и хроническая сердечная недостаточность [33, 50, 74, 75]. Влияние депрессии и тревоги на течение этих заболеваний оказалось не менее значимым, чем влияние их соматических характеристик. Выявлены 11 хронических заболеваний, несущих максимальное бремя для общества. Среди них особо отмечены ревматоидный артрит (РА) и депрессия [57], а D.Granados и соавт. (2005 г.) выделяют среди шести ведущих приоритетов здравоохранения депрессию и артрит1. W.Katon и соавт. (2007 г.) подчеркивают необходимость оптимизации медицинской помощи этой категории пациентов и, соответственно, правильной и своевременной диагностики.
В отличие от других хронических заболеваний (ишемической болезни сердца, гипертонической болезни, хронической обстр...
Depression and rheumatoid arthritis, combination in rheumatoid practice (literature review)
E.A.Grigorieva, N.V.Yalceva, N.I.Korshunov
Yaroslavl state medical academy
Депрессия в ее различных клинических вариантах признается одной из основных причин снижения трудоспособности; по доле потерянных для полноценной жизни лет депрессивные расстройства в настоящее время опережают все прочие психические заболевания. К 2020 г. депрессии займут 2-е место среди всех заболеваний по интегративной оценке бремени, которое несет общество, уступая только ишемической болезни сердца. Особенно высока доля лиц, страдающих депрессиями, среди пациентов общесоматической сети [11, 52]. При этом как депрессия, так и хроническая боль у женщин встречаются в 2 раза чаще, чем у мужчин.
При исследовании распространенности хронической соматической патологии 62,5% населения имеют по крайней мере одно хрониÑ...
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Вход / Регистрация- Примечания
- 1Коморбидные связи между депрессией и РА имеют, очевидно, патогенетические основы. Психонейроиммунология накапливает свидетельства существования взаимных обратных связей между психическими, эндокринными и иммунной системами [3, 10, 27, 78, 80, 102]. В настоящее время обсуждается роль таких провоспалительных цитокинов, как, например, интерлейкин-1, фактор некроза опухоли-a (TNF-a), интерферон-g (IFN-g) в этиологии и патофизиологии депрессии. «Цитокиновая» гипотеза депрессии предполагает, что провоспалительные цитокины, действуя как нейромодуляторы, представляют ключевой показатель в посредничестве центральных поведенческих, нейроэндокринных и нейрохимических характеристик депрессивных симптомов. Соматическое заболевание, которое характеризуется хроническим воспалительным процессом, например РА, согласно данной теории будет сопровождаться аналогичными сдвигами. Хронический либо острый дистресс приводит к дизрегуляции в системе цитокинов, что в свою очередь может инициировать дизрегуляцию гипоталамо-гипофизарно-надпочечниковой и гипофизарно-гипоталамо-тиреоидной осей. Такие закономерности установлены не только при депрессии, но и при РА [22]. Центральные эффекты провоспалительных цитокинов влияют на основные симптомы депрессии, однако данная проблема требует более глубокого изучения [78].
- 2Так, нарушения семейного функционирования отмечено у 39% пациентов с РА [8]. При этом депрессия, боль и возраст у больных РА – факторы, снижающие сексуальное влечение и удовлетворение [1, 6].
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