Всемирная психиатрия. №2 2019

Изучение независимых и сопряженных эффектов молекулярной генетической предрасположенности и средовых воздействий при шизофрении: результаты исследования EUGEI

Sinan Guloksuz1,2, Lotta-Katrin Pries1, Philippe Delespaul1, Gunter Kenis1, Jurjen J. Luykx3-5, Bochao D. Lin4, Alexander L. Richards6, Berna Akdede7, Tolga Binbay7, Vesile Altınyazar8, Berna Yalınçetin9, Güvem Gümüs¸ Akay10, Burçin Cihan11, Haldun Soygür12, Halis Ulas13, Eylem Şahin Cankurtaran14, Semra Ulusoy Kaymak15, Marina M. Mihaljevic16,17, Sanja Andric Petrovic17, Tijana Mirjanic18, Miguel Bernardo19-21, Bibiana Cabrera19,21, Julio Bobes21-24, Pilar A. Saiz21-24, María Paz García-Portilla21-24, Julio Sanjuan21,25, Eduardo J. Aguilar21,25, José Luis Santos21,26, Estela Jiménez-López21,27, Manuel Arrojo28, Angel Carracedo29, Gonzalo López21,30, Javier González Penas21,30, Mara Parellada21,30, Nadja P. Maric16,17, Cem Atbaşoğlu31, Alp Ucok32, Köksal Alptekin7, Meram Can Saka31, Genetic Risk and Outcome of Psychosis (GROUP) investigators*, Celso Arango21,30, Michael O’Donovan6, Bart P.F. Rutten1, Jim van Os1,3,33

1Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; 2Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; 3Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; 4Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; 5GGNet Mental Health, Apeldoorn, The Netherlands; 6MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK; 7Department of Psychiatry, Dokuz Eylül University School of Medicine, Izmir, Turkey; 8Department of Psychiatry, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey; 9Department of Neuroscience, Health Sciences Institute, Dokuz Eylül University, Izmir, Turkey; 10Ankara University Brain Research Center, Ankara, Turkey; 11Department of Psychology, Middle East Technical University, Ankara, Turkey; 12Turkish Federation of Schizophrenia Associations, Ankara, Turkey; 13Department of Psychiatry, School of Medicine, Dokuz Eylül University (discharged by decree 701 on July 8, 2018 because of signing “Peace Petition”); 14Güven Çayyolu Healthcare Campus, Ankara, Turkey; 15Atatürk Research and Training Hospital Psychiatry Clinic, Ankara, Turkey; 16Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 17Clinic for Psychiatry CCS, Belgrade, Serbia; 18Special Hospital for Psychiatric Disorders Kovin, Kovin, Serbia; 19Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain; 20Institut d’Investigacions Biomèdiques August Pi I Sunyer, Barcelona, Spain; 21Biomedical Research Networking Centre in Mental Health (CIBERSAM), Spain; 22Department of Psychiatry, School of Medicine, University of Oviedo, Oviedo, Spain; 23Instituto de Investigaciуn Sanitaria del Principado de Asturias, Oviedo, Spain; 24Mental Health Services of Principado de Asturias, Oviedo, Spain; 25Department of Psychiatry,Hospital Clнnico Universitario de Valencia, School of Medicine, Universidad de Valencia, Valencia, Spain; 26Department of Psychiatry, Hospital Virgen de la Luz, Cuenca, Spain; 27Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain; 28Department of Psychiatry, Instituto de Investigaciуn Sanitaria, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain; 29Fundaciуn Publica Galega de Medicina Xenómica, Universidad de Santiago de Compostela, Santiago de Compostela, Spain; 30Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Maraсуn, Universidad Complutense, Madrid, Spain; 31Department of Psychiatry, School of Medicine, Ankara University, Ankara, Turkey; 32Department of Psychiatry, Faculty of Medicine, Istanbul University, Istanbul, Turkey; 33Department of Psychosis Studies, King’s College London, Institute of Psychiatry, London, UK *The Genetic Risk and Outcome of Psychosis (GROUP) investigators in EUGEI are listed in the Appendix

Стр. 178-188

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Опубликовано: 15 мая 2019

Аннотация / Abstract

a:2:{s:4:"TEXT";s:65525:"a:2:{s:4:"TYPE";s:4:"HTML";s:4:"TEXT";s:65783:"Перевод: Шишковская Т.И. (Москва) Редактура: к.м.н. Федотов И.А. (Рязань) Guloksuz S et al. Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study. World Psychiatry 2019;18(2):173-182. Шизофрения в настоящее время представляется комплексным наследуемым фенотипом. С одной стороны, он ассоциирован с генетической предиспозицией, при этом вклад каждой из многочисленных и распространенных вариаций по отдельности невелик. С другой стороны, существует множество значимых средовых воздействий. Близнецовые и семейные исследования, которые ранее использовались в качестве замены прямых методов выявления генетического риска, позволяют предположить взаимодействие генетических и средовых факторов в этиологии шизофрении, но молекулярно-генетические данные достаточно скудны. Данный материал также раскрывает тему взаимодействия генетических и средовых факторов в генезе шизофрении: в нем проанализированы основные и сочетанные ассоциации уровня полигенного риска шизофрении (PRS-SCZ) и средовых воздействий у 1699 пациентов с диагнозом расстройств шизофренического спектра и 1542 представителей контрольной группы без соответствующих расстройств в анамнезе. Выявлена суммация эффекта состояния молекулярно-генетического риска шизофрении (бинарная модель PRS-SCZ более 75% от контрольного распределения) и такими внешними факторами, как регулярное употребление каннабиса на протяжении жизни и подверженность негативному воздействию в раннем возрасте (сексуальное и эмоциональное насилие, эмоциональная депривация, травля), но не выявлено взаимодействия с такими факторами, как нарушение слуха, время года, на которое приходится дата рождения, а также подверженность физическому насилию и депривации физических потребностей в детстве. Анализ чувствительности, в котором изначально выбранный уровень PRS-SCZ в 75% был зам...

Перевод: Шишковская Т.И. (Москва) Редактура: к.м.н. Федотов И.А. (Рязань) Guloksuz S et al. Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study. World Psychiatry 2019;18(2):173-182. Шизофрения в настоящее время представляется комплексным наследуемым фенотипом. С одной стороны, он ассоциирован с генетической предиспозицией, при этом вклад каждой из многочисленных и распространенных вариаций по отдельности невелик. С другой стороны, существует множество значимых средовых воздействий. Близнецовые и семейные исследования, которые ранее использовались в качестве замены прямых методов выявления генетического риска, позволяют предположить взаимодействие генетических и средовых факторов в этиологии шизофрении, но молекулярно-генетические данные достаточно скудны. Данный материал также раскрывае...

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Изучение независимых и сопряженных эффектов молекулярной генетической предрасположенности и средовых воздействий при шизофрении: результаты исследования EUGEI

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Изучение независимых и сопряженных эффектов молекулярной генетической предрасположенности и средовых воздействий при шизофрении: результаты исследования EUGEI

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