Психические расстройства в общей медицине. №4 2016

Нейроэндокринные опухоли и психические расстройства (обзор литературы)

М.Р.Шафигуллин1, Д.С.Петелин1,2

1ФГБНУ Научный центр психического здоровья. 115522, Россия, Москва, Каширское ш., д. 34; 2ФГБОУ ВО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2

Стр. 34-38

2022 просмотров

Опубликовано: 15 декабря 2016

Аннотация / Abstract

Представлен анализ литературы, посвященной психическим расстройствам при нейроэндокринных опухолях (тревожные, аффективные расстройства, нарушения импульс-контроля, психозы, когнитивные нарушения); обсуждается вклад нозо- и соматогенных факторов в их происхождение. Особое внимание уделяется парадоксальному дефициту серотонина в центральной нервной системе, детерминирующему развитие соматогенных психических расстройств. Обсуждаются также аспекты эффективности и переносимости антидепрессивной терапии при опухолях, продуцирующих серотонин. Ключевые слова: нейроэндокринные опухоли, карциноид, серотонин, импульсивность, психоонкология. petelinhome1@yandex.ru Для цитирования: Шафигуллин М.Р., Петелин Д.С. Нейроэндокринные опухоли и психические расстройства (обзор литературы). Психические расстройства в общей медицине. 2016; 4: 34–38. Psychiatric disorders in neuroendocrine tumors (a literature review) M.R.Shafigullin1, D.S.Petelin1,2 1 Mental Health Research Centre. 115522, Russian Federation, Moscow, Kashirskoe sh., d. 34; 2 I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2 The review is dedicated to problem of psychiatric comorbodities in neuroendocrine tumors (anxious, mood, impulse-control disorders, psychoses, cognitive impairment). Role of noso- (semantics and significance of disorder) and somatogenic (direct impact of disorder) factors in development of psychiatric comorbidities is discussed. Parodoxial deficiency of serotonin in central nervous system as cause of somatogenic disorders in neuroendocrine tumors is stressed. Special attention is gained to the problem of efficiency and tolerability of antidepressive treatment (namely selective serotonin re-uptake inhibitors treatment) in neuroendocrine treatment. Key words: neuroendocrine tumors, carcinoid, serotonin, impulsivity, psychooncology. petelinhome1...

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Вход / Регистрация

1. Бохян В.Ю., Бельцевич Д.Г., Вашакмадзе Л.А. и др. Клинические рекомендации по лечению нейроэндокринных опухолей. М., 2014. / Bokhyan V.Yu., Bel'tsevich D.G., Vashakmadze L.A. et al. Klinicheskie rekomendatsii po lecheniiu neiroendokrinnykh opukholei. M., 2014. [in Russian]
2. Baba M, Ray D. Severe psychosis due to Cushing's syndrome in a patient with a carcinoid tumour in the lung: a case report and review of the current management. World J Surg Oncol 2015; 13: 165.
3. Baiwah S, Lee B. The case study master class. Case 20% symptom control in patient with carcinoid tumor. Eur J Palliative Care 2005; 12: 106–7.
4. Bariani G, Carvalheira J, Riechelmann R. Antitumor effect of everolimus in a patient with type 3 gastric neuroendocrine tumor. Onkologie 2013; 36 (9): 502–4.
5. Chambers A, Longman R, Pasieka J. Impairment of cognitive function reported by patients suffering from carcinoid syndrome. World J Surg 2010; 34 (6): 1356–60.
6. Curzon G. Tryptophan pyrrolase – a biochemical factor in depressive illness. Br J Psychiatry 1969; 113: 1367–74.
7. Edge J, Panieri E. Phaeochromocytoma – a classic (but easily forgotten) cause of anxiety. Afr J Psychiatry (Johannesbg) 2011; 14 (2): 154–56.
8. Engelmann K, Lovenberg W, Sjoerdsma A. Inhibition of serotonin synthesis by para-chlorophenylalanine in patients with the carcinoid syndrome. N Engl J Med 1967; 277 (21): 1103–8.
9. Eriksson B, Oberg K. Summing up 15 years of somatostatin analog therapy in neuroendocrine tumors: future outlook. Ann Oncol 1999; 10 (2): 31–8.
10. Frojd C, Lampic C, Larsson G et al. Is satisfaction with doctors' care related to health-related quality of life, anxiety and depression among patients with carcinoid tumours? A longitudinal report. Scand J Caring Sci 2009; 23 (1): 107–16.
11. Furse R, Green C, Mee A. Carcinoid syndrome unmasked by fluoxetine, a selective serotonin reuptake inhibitor. Clin Gastroenterol Hepatol 2008; 6 (8): e27–8.
12. Grahame-Smith D. The carcinoid syndrome. Am J Cardiol 1968; 21 (3): 376–87.
13. Horst-Schrivers A, Wymenga A, Links T et al. Complication of midgut carcinoid tumors and carcinoid syndrom. Neuroendocrinology 2004; 80 (1): 28–32.
14. Janson I, Holmberg E, Strdsberg R et al. Carcinoid tumors: analysis of prognostic factors and survival in 301 patients from a referral center. Ann Oncol 1997; 8 (7): 685–90.
15. Larsson G, Haguind K, Von Essen L. Distress, quality of life and strategies to 'keep a good mood' in patients with carcinoid tumours: patient and staff perceptions. Eur J Cancer Care (Engl) 2003; 12 (1): 46–57.
16. Lehmann J. Mental disturbancies followed by stupor in a patient with carcinoid. Acta Psychiatr Scand 1966; 42: 153–61.
17. Major L, Brown G, Wilson W. Carcinoid and psychiatric symptoms. South Med J 1973; 66 (7): 787–90.
18. Modlin I, Shapiro M, Kidd M. Siegfried Oberndorfer: Origins and perspectives of carcinoid tumors. Hum Pathol 2004; 35 (12): 1440–51.
19. Moretti P, Dennis J, Stella A et al. Comorbility between anxiety and depression in patients with carcinoid tumors. Rivisita di Psichiatria 2013; 48 (4): 301–6.
20. Noblett J. The presence and management of depression in patients with carcinoid. BMJ 2010; 341: 39–41.
21. Norheim I, Oberg K, Theodorsson-Norheim T et al. Malignant carcinoid tumors. An analysis of 103 patients with regard to tumor localization, hormone production, and survival. Ann Surg 1987; 206 (2): 115–25.
22. Noyer C, Schwartz B. Sertraline, a selective serotonin reuptake inhibitor, unmasking carcinoid syndrome. Am J Gastroenterol 1997; 92 (8): 1387–8.
23. Oberg K, Castellano D. Current knowledge on diagnosis and staging of neuroendocrine tumors. Cancer Metast Rev 2011; 30: 3–7.
24. Pasieka J, Longman R, Chambers A et al. Cognitive impairment associated with carcinoid syndrome. Ann Surg 2014; 259 (2): 355–9.
25. Patchell R, Posner J. Neurologic complications of carcinoid. Neurology 1986; 36 (6): 745–9.
26. Pearse A. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 1969; 17 (5): 303–13.
27. Russo S, Boon J, Kema I et al. Patients with carcinoid syndrome exhibit symptoms of aggressive impulse dysregulation. Psychosom Med 2004; 66 (3): 422–5.
28. Savitz J, Dantzer R, Wurfel B. Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology 2015; 52: 200–11.
29. Shoukry H. Carcinoid syndrom associated with psychosis. Postgrad Med 1965; 41: 566–7.
30. Simbera Z, Balon R. Carcinoid tumor, selective serotonin reuptake inhibitors, and diarrhea. Psychosomatics 2005; 46 (1): 88–9.
31. Sokoloff B. Recent results in cancer research. Carcinoid and serotonin. Springer Verlag 1968; 15: 34–43.
32. Thorson A. Studies on carcinoid disease. Acta Med Scand 1958; 161: 1–146.
33. Warner R. Enteroendocrine Tumors Other Than Carcinoid: A Review of Clinically Significant Advances. Gastroenterology 2005; 128 (6): 1668–84.
34. Williams M, Dolenc T. Selective serotonin reuptake inhibitors and patients with carcinoid tumor. Psychosomatics 2005; 46 (4): 370–2.
35. Wooley O. The biochemical basis of psychosis. New-York: John Wiley & Sons, 1962.
36. Yazıcıoğlu A, Yekeler E, Bıcakcıoğlu P et al. Synchronous bilateral multiple typical pulmonary carcinoid tumors: a unique case with 10 typical carcinoids. Balkan Med J 2012; 29 (4): 450–2.

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Нейроэндокринные опухоли и психические расстройства (обзор литературы)

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ИЗДАНИЯ-ПАРТНЕРЫ

Нейроэндокринные опухоли и психические расстройства (обзор литературы)

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