О механизмах противоопухолевого действия соединений трополонового ряда
Исследования и практика в медицине. №3 2021
О механизмах противоопухолевого действия соединений трополонового ряда
Г.В.Жукова*, Е.А.Лукбанова, Т.П.Протасова, Е.В.Заикина, А.А.Киблицкая
ФГБУ «НМИЦ онкологии» Минздрава России, 344037, Российская Федерация, г. Ростов-на-Дону, ул. 14-я линия, д. 63
Стр. 118-132
999 просмотров
Опубликовано: 1 ноября 2021
Аннотация / Abstract
Показана перспективность использовавния производных 2‑хинолил 1,3‑трополона и связь их противоопухолевого действия с индукцией апоптоза и изменением активности сигнального пути ERK в некоторых типах малигнизированных клеток. Полученные результаты свидетельствуют о многообразии возможных путей влияния трополонов на состояние злокачественных клеток, условия реализации каждого из которых нуждаются в уточнении, особенно при дефиците сведений о процессах in vivo.
В обзоре использованы сведения литературы, представленной в базах данных Scopus, WoS, Pubmed. 35 % работ опубликовано за последние 5 лет.
Показана перспективность использовавния производных 2‑хинолил 1,3‑трополона и связь их противоопухолевого действия с индукцией апоптоза и изменением активности сигнального пути ERK в некоторых типах малигнизированных клеток. Полученные результаты свидетельствуют о многообразии возможных путей влияния трополонов на состояние злокачественных клеток, условия реализации каждого из которых нуждаются в уточнении, особенно при дефиците сведений о процессах in vivo.
В обзоре использованы сведения литературы, представленной в базах данных Scopus, WoS, Pubmed. 35 % работ опубликовано за последние 5 лет....
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