Всемирная психиатрия. №2 2018

Психические расстройства у семилетних детей с высоким семейным риском развития психозов шизофренического спектра или биполярного расстройства – «Датское исследование высокого риска и устойчивости у 7-летних», популяционное когортное исследование

Ditte Ellersgaard1–3, Kerstin Jessica Plessen2–4, Jens Richardt Jepsen2,4,5, Katrine Soeborg Spang2–4, Nicoline Hemager1–4, Birgitte Klee Burton2–4, Camilla Jerlang Christiani1–3, Maja Gregersen1,2, Anne Søndergaard1,2, Md Jamal Uddin1,2,6, Gry Poulsen1,2,6, Aja Greve2,7, Ditte Gantriis2,7, Ole Mors2,7, Merete Nordentoft1–3, Anne Amalie Elgaard Thorup2–4

1Mental Health Services – Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark; 2The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark; 3Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 4Mental Health Services – Capital Region of Denmark, Child and Adolescent Mental Health Centre, Copenhagen, Denmark; 5Mental Health Services – Capital Region of Denmark, Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Copenhagen, Denmark; 6Department of Public Health – Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark; 7Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark

Стр. 206-215

1834 просмотров

Опубликовано: 12 ноября 2018

Аннотация / Abstract

Перевод: Симонов Р.В. (Санкт-Петербург) Редактура: к.м.н. Чумаков Е.М. (Санкт-Петербург) Это исследование направлено на сравнение профилей психических расстройств у детей с высоким семейным риском развития психозов шизофренического спектра (FHR-SZ) или биполярного расстройства (FHR-BP) с популяционными показателями. Мы использовали датские национальные реестры для выделения когорты из 522 семилетних детей, родители которых страдали психозами шизофренического спектра (n=202), биполярным расстройством (n=120) или не имели ни одного из этих расстройств (n=200). Психические расстройства оценивались на основании сообщений различных информаторов, среди которых были дети, родители и учителя. «Ослепленными» рейтерами с помощью Диагностической шкалы для аффективных расстройств и шизофрении для детей школьного возраста были верифицированы соответствовавшие критериям диагнозов DSM-IV психические расстройства в течение жизни. Количественную оценку выраженности психических расстройств проводили с помощью Листа оценки детского поведения (Child Behavior Checklist), Форм отчета учителей (Teacher’s Report Form), модифицированной версии Шкалы оценки СДВГ (ADHD-Rating Scale), Формы тестового наблюдения (The Test Observation Form – TOF) и Шкалы реактивной и личностной тревожности для детей (State-Trait Anxiety Inventory for Children). Текущий уровень функционирования оценивался с использованием Шкалы общей оценки ребенка (Children’s Global Assessment Scale – CGAS). Распространенность психиатрических диагнозов в течение жизни была значительно выше у детей из группы FHR-SZ [38,7%, отношение шансов (ОШ) 3,5; 95% доверительный интервал (ДИ) 2,2–5,7; p

Материал для специалистов

Полный текст статьи доступен только зарегистрированным пользователям.

Вход / Регистрация

1. Fusar-Poli P, McGorry PD, Kane JM. Improving outcomes of first-episode psychosis: an overview. World Psychiatry 2017;16:251-65.
2. Yung AR. Treatment of people at ultra-high risk for psychosis. World Psychiatry 2017;16:207-8.
3. Rapoport JL, Giedd JN, Gogtay N. Neurodevelopmental model of
schizophrenia: upd ate 2012. Mol Psychiatry 2012;17:1228-38.
4. Owen MJ, O’Donovan MC. Schizophrenia and the neurodevelopmental continuum: evidence from genomics. World Psychiatry 2017;16:227-35
5. Laurens KR, Luo L, Matheson SL et al. Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses. BMC Psychiatry 2015;15:205.
6. Dean K, Stevens H, Mortensen PB et al. Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder. Arch Gen Psychiatry 2010;67:822-9.
7. Rasic D, Hajek T, Alda M et al. Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies. Schizophr Bull 2014;40:28-38.
8. De la Serna E, Baeza I, Andres S et al. Comparison between young siblings and offspring of subjects with schizophrenia: clinical and neuropsychological characteristics. Schizophr Res 2011;131:35-42.
9. Keshavan M, Montrose DM, Rajarethinam R et al. Psychopathology among offspring of parents with schizophrenia: relationship to premorbid impairments. Schizophr Res 2008;103:114-20.
10. Ross RG, Compagnon N. Diagnosis and treatment of psychiatric disorders in children with a schizophrenic parent. Schizophr Res 2001;50:121-9.
11. Hans SL, Auerbach JG, Styr B et al. Offspring of parents with schizophre-nia: mental disorders during childhood and adolescence. Schizophr Bull 2004;30:303-15.
12. Sanchez-Gistau V, Romero S, Moreno D et al. Psychiatric disorders in child and adolescent offspring of patients with schizophrenia and bipolar disor-der: a controlled study. Schizophr Res 2015;168:197-203.
13. Donatelli JA, Seidman LJ, Goldstein JM et al. Children of parents with affective and nonaffective psychoses: a longitudinal study of behavior problems. Am J Psychiatry 2010;167:1331-8.
14. Dworkin RH, Green SR, Small NE et al. Positive and negative symptoms and social competence in adolescents at risk for schizophrenia and affective disorder. Am J Psychiatry 1990;147:1234-6.
15. Niemi LT, Suvisaari JM, Tuulio-Henriksson A et al. Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies. Schizophr Res 2003;60:239-58.
16. Birmaher B, Axelson D, Monk K et al. Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring study. Arch Gen Psychiatry 2009;66:287-96.
17. Chang K, Steiner H, Ketter T. Studies of offspring of parents with bipolar disorder. Am J Med Genet 2003;123C:26-35.
18. Henin A, Biederman J, Mick E et al. Psychopathology in the offspring of parents with bipolar disorder: a controlled study. Biol Psychiatry 2005;58:554-61.
19. Vandeleur C, Rothen S, Gholam-Rezaee M et al. Mental disorders in off-spring of parents with bipolar and major depressive disorders. Bipolar Disord 2012;14:641-53.
20. Frıas A, Palma C, Farriols N et al. Characterizing offspring of bipolar parents: a review of the literature. Actas Esp Psiquiatr 2015;43:221-34.
21. Singh MK, DelBello MP, Stanford KE et al. Psychopathology in children of bipolar parents. J Affect Disord 2007;102:131-6.
22. Moron-Nozaleda MG, Dıaz-Caneja CM, Rodriguez-Toscano E et al.
A developmental approach to dimensional expression of psychopathology in child and adolescent offspring of parents with bipolar disorder. Eur Child Adolesc Psychiatry 2017;26:1165-75.
23. Mesman E, Birmaher BB, Goldstein BI et al. Categorical and dimensional psychopathology in Dutch and US offspring of parents with bipolar disorder: a preliminary cross-national comparison. J Affect Disord 2016;205:95-102.
24. Diler RS, Birmaher B, Axelson D et al. Dimensional psychopathology in offspring of parents with bipolar disorder. Bipolar Disord 2011;13:670-8.
25. Giles LL, DelBello MP, Stanford KE et al. Child behavior checklist profiles of children and adolescents with and at high risk for developing bipolar disorder. Child Psychiatry Hum Dev 2007;38:47-55.
26. Dienes KA, Chang KD, Blasey CM et al. Characterization of children of bipolar parents by parent report CBCL. J Psychiatr Res 2002;36:337-45.
27. Egeland JA, Shaw JA, Endicott J et al. Prospective study of prodromal features for bipolarity in well Amish children. J Am Acad Child Adolesc Psychiatry 2003;42:786-96.
28. Maoz H, Goldstein T, Axelson DA et al. Dimensional psychopathology in preschool offspring of parents with bipolar disorder. J Child Psychol Psychiatry 2014;55:144-53.
29. Duffy A, Horrocks J, Doucette S et al. The developmental trajectory of bipolar disorder. Br J Psychiatry 2014;204:122-8.
30. Goetz M, Sebela A, Mohaplova M et al. Psychiatric disorders and quality of life in the offspring of parents with bipolar disorder. J Child Adolesc Psychopharmacol 2017;27:483-93.
31. Maziade M, Gingras N, Rouleau N et al. Clinical diagnoses in young offspring from eastern Quebec multigenerational families densely affected by schizophrenia or bipolar disorder. Acta Psychiatr Scand 2008;117:118-26.
32. Thorup AAE, Jepsen JR, Ellersgaard DV et al. The Danish High Risk and Resilience Study – VIA 7 – a cohort study of 520 7-year-old children born of parents diagnosed with either schizophrenia, bipolar disorder or neither of these two mental disorders. BMC Psychiatry 2015;15:233.
33. Pedersen CB. The Danish Civil Registration System. Scand J Publ Health 2011;39(Suppl. 7):22-5.
34. Mors O, Perto GP, Mortensen PB. The Danish Psychiatric Central Research Register. Scand J Publ Health 2011;39(Suppl. 7):54-7.
35. Kaufman J, Birmaher B, Brent D et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children – Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997;36:980-8.
36. Shaffer D. A Children’s Global Assessment Scale (CGAS). Arch Gen Psychiatry 1983;40:1228.
37. Achenbach TM, Rescorla LA. Manual for the ASEBA School-Age Forms & Profiles. Burlington: University of Vermont, Research Center for Children, Youth, & Families, 2001.
38. Makransky G, Bilenberg N. Psychometric properties of the parent and teacher ADHD Rating Scale (ADHD-RS): measurement invariance across gender, age, and informant. Assessment 2014;21:694-705.
39. DuPaul G, Power TJ, Anastopoulos A et al. ADHD Rating Scale-IV. New York: Guilford, 1998.
40. Barkley R, Gwenyth EH, Arthur LR. Defiant teens. A clinician’s manual for assessment and family intervention. New York: Guilford, 1999.
41. McConaughy SH, Achenbach TM. Manual for the Test Observation Form for ages 2-18. Burlington: University of Vermont, Center for Children, Youth, & Families, 2004.
42. Spielberger CD, Edwards CD, Lushene R et al. State-Trait Anxiety Inventory for Children: sampler se t, manual, test booklet, scoring key. Palo Alto: Mind Garden, 1973.
43. Zapf A, Castell S, Morawietz L et al. Measuring inter-rater reliability for nominal data – which coefficients and confidence intervals are appropriate? BMC Med Res Methodol 2016;16:93.
44. Duffy A, Horrocks J, Doucette S et al. Childhood anxiety: an early predictor of mood disorders in offspring of bipolar parents. J Affect Disord 2013;150:363-9.
45. Duffy A, Doucette S, Lewitzka U et al. Findings from bipolar offspring studies: methodology matters. Early Interv Psychiatry 2011;5:181-91.
46. Keshavan MS, Sujata M, Mehra A et al. Psychosis proneness and ADHD in young relatives of schizophrenia patients. Schizophr Res 2003;59:85-92.
47. Duffy A. The nature of the association between childhood ADHD and the development of bipolar disorder: a review of prospective high-risk studies. Am J Psychiatry 2012;169:1247-55.
48. Maoz H, Goldstein T, Goldstein BI et al. The effects of parental mood on reports of their children’s psychopathology. J Am Acad Child Adolesc Psychiatry 2014;53:1111-22.e5.

ЖУРНАЛЫ

ИНТЕРАКТИВ

СПЕЦИАЛИЗАЦИИ

ИЗДАНИЯ-ПАРТНЕРЫ

Материал для специалистов

ЖУРНАЛЫ

ИНТЕРАКТИВ

СПЕЦИАЛИЗАЦИИ

ИЗДАНИЯ-ПАРТНЕРЫ

Материал для специалистов

Con-Med Passport