Всемирная психиатрия. №2 2016

Сахарный диабет при шизофрении, биполярном расстройстве, большом депрессивном расстройстве: систематический обзор и крупномасштабный мета-анализ

Davy Vancampfort1,2, Christoph U. Correll3,4, Britta Galling3, Michel Probst1, Marc De Hert2, Philip B. Ward5, Simon Rosenbaum5, Fiona Gaughran6, John Lally6, Brendon Stubbs6-8

1KU Leuven - University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium; 2KU Leuven - University of Leuven, Z.org KU Leuven, Kortenberg, Belgium; 3Zucker Hillside Hospital, Glen Oaks, NY, USA; 4Hofstra North Shore LIJ School of Medicine, Hempstead, NY, USA; 5School of Psychiatry and Ingham Institute of Applied Medical Research, University of New South Wales, Sydney, Australia; 6Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, UK; 7Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK; 8Health Service and Population Research Department, Institute of Psychiatry, King’s College London, London, UK

Стр. 166-174

1852 просмотров

Опубликовано: 1 июня 2016

Аннотация / Abstract

Сахарный диабет II типа (СД2Т) значительно повышает риск развития сердечно-сосудистых заболеваний и может пагубно влиять на здоровье людей с тяжелыми психическими расстройствами (ТПР), т. е. шизофренией, биполярным расстройством или большим депрессивным расстройством. Целями данного мета-анализа стали: а) описание частотности СД2Т у людей с ТПР б) анализ влияния демографических факторов, особенностей болезни и лечения, а также методов оценки риска СД2Т в) описание уровня заболеваемости СД2Т на основании исследований, сравнивающих людей с определенными ТПР и популяцию в целом. Распространенность СД2Т, скорректированная методом обрезки и заполнения (trim and fill), на выборке из 438245 человек с ТПР составила 11,3% (95% CI: 10.0%-12.6%). У не принимавших антипсихотики пациентов распространенность СД2Т составила 2.9% (95% CI: 1.7%-4.8%). Значительной разницы в диагностических подгруппах выявлено не было. Сравнительный мета-анализ установил, что у людей с множественными эпизодами ТПР (N=133,470) вероятность СД2Т значительно выше, чем у соответствующей контрольной группы (N=5,622,664): относительный риск, RR=1.85, 95% CI: 1.45-2.37, p

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Вход / Регистрация

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Сахарный диабет при шизофрении, биполярном расстройстве, большом депрессивном расстройстве: систематический обзор и крупномасштабный мета-анализ

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Сахарный диабет при шизофрении, биполярном расстройстве, большом депрессивном расстройстве: систематический обзор и крупномасштабный мета-анализ

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