Всемирная психиатрия. №1 2020

Сетевой метаанализ эффектов психотерапии, фармакотерапии и их комбинации при лечении депрессии у взрослых

Pim Cuijpers1, Hisashi Noma2, Eirini Karyotaki1, Christiaan H. Vinkers3,4, Andrea Cipriani5,6, Toshi A. Furukawa7

1Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; 2Department of Data Science, Institute of Statistical Mathematics, Tokyo, Japan; 3Department of Psychiatry, Amsterdam UMC (location VUmc), Amsterdam, The Netherlands; 4Department of Anatomy and Neurosciences, Amsterdam UMC (location VUmc), Amsterdam, The Netherlands; 5Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; 6Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK; 7Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine, School of Public Health, Kyoto, Japan

Стр. 91-106

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Опубликовано: 12 февраля 2020

Аннотация / Abstract

a:2:{s:4:"TEXT";s:65524:"a:2:{s:4:"TYPE";s:4:"HTML";s:4:"TEXT";s:65862:"Перевод: Суслова Ж. В. (Москва) Редактура: к.м.н. Федотов И.А. (Рязань) Cuijpers P, Noma H, Karyotaki E, Vinkers C H, Cipriani A, Furukawa T A. A network meta-analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression. World Psychiatry 2020;19(1):92–107. Резюме Сетевой метаанализ относительных эффектов психотерапии, фармакотерапии и их комбинации при лечении депрессии у взрослых не выполнялся, хотя это представляет собой очень важную клиническую проблему. Мы выполнили систематический поиск в библиографических базах данных для отбора рандомизированных исследований, в которых психотерапия и фармакотерапия при кратковременном или долговременном лечении депрессии сравнивались между собой, или комбинация психотерапии и фармакотерапии – с каждой их них в отдельности. Основным исходом считался отклик на лечение (улучшение на 50% при сопоставлении начальной и конечной точек лечения). Также принимались во внимание ремиссия и переносимость (определяемая как выбытие участников из исследования по любым причинам). В качестве возможных переменных-модераторов оценивались хроническая и терапевтически резистентная депрессия и исходная тяжесть депрессии. Данные были объединены для оценки относительного риска (relative risk – RR) c использованием модели случайных эффектов. Было охвачено 101 исследование с участием 11 910 пациентов. В большинстве исследований речь шла о депрессии от умеренной до тяжелой степени. В сетевом метаанализе комбинированное лечение продемонстрировало большую эффективность по сравнению с только психотерапией (RR=1,27; 95% доверительный интервал (95% ДИ): 1,14–1,39) и только фармакотерапией (RR=1,25; 95% ДИ: 1,14–1,37) в достижении отклика в конце лечения. Не было выявлено значимых различий между только психотерапией и только фармакотерапией (RR=0,99; 95% ДИ: 0,92–1,08). Похожие результаты были получены для ремисс...

Перевод: Суслова Ж. В. (Москва) Редактура: к.м.н. Федотов И.А. (Рязань) Cuijpers P, Noma H, Karyotaki E, Vinkers C H, Cipriani A, Furukawa T A. A network meta-analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression. World Psychiatry 2020;19(1):92–107. Резюме Сетевой метаанализ относительных эффектов психотерапии, фармакотерапии и их комбинации при лечении депрессии у взрослых не выполнялся, хотя это представляет собой очень важную клиническую проблему. Мы выполнили систематический поиск в библиографических базах данных для отбора рандомизированных исследований, в которых психотерапия и фармакотерапия при кратковременном или долговременном лечении депрессии сравнивались между собой, или комбинация психотерапии и фармакотерапии – с каждой их них в отдельности. Основным исходом считался отклик на лечение (улучшение на 50% при сопоставлении нач�...

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Сетевой метаанализ эффектов психотерапии, фармакотерапии и их комбинации при лечении депрессии у взрослых

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