Всемирная психиатрия. №1 2020

20-летнее катамнестическое исследование соматической заболеваемости и смертности у больных шизофренией на антипсихотической терапии в общенациональной когорте из 62 250 пациентов (fin20)

Heidi Taipale1-3, Antti Tanskanen1,2,4, Juha Mehtälä5, Pia Vattulainen5, Christoph U. Correll6-9, Jari Tiihonen1,2,10

1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; 2Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; 3School of Pharmacy, University of Eastern Finland, Kuopio, Finland; 4Public Health Evaluation and Projection Unit, National Institute for Health and Welfare, Helsinki, Finland; 5EPID Research Oy, Espoo, Finland; 6Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; 7Department of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; 8Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA; 9Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany; 10Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden

Стр. 61-68

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Опубликовано: 12 февраля 2020

Аннотация / Abstract

Перевод: Павлова-Воинкова Е.Е. (Санкт-Петербург) Редактура: к.м.н. Федотов И.А. (Рязань) Taipale H, Tanskanen A, Mehtälä J, Vattulainen P, Correll CU, Tiihonen J. 20-year follow-up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20). World Psychiatry 2020; 19 (1): 61-68. Резюме Антипсихотики эффективны в отношении предотвращения рецидивов при шизофрении, но считается, что их длительное применение вредит соматическому благополучию пациентов. Тем не менее, нет долгосрочных исследований, подтверждающих эту точку зрения. Целью представленного общенационального, когортного исследования, основанного на регистрах данных, явилась оценка риска госпитализации из-за проблем с физическим здоровьем как маркера заболеваемости тяжелыми соматическими болезнями, риска смертности от всех причин, а также смертности от сердечно-сосудистых заболеваний и смертности от самоубийств, связанных с приемом антипсихотических препаратов среди всех больных шизофренией, находившихся на стационарном лечении с 1972 по 2014 год в Финляндии (N=62 250) с периодом катамнестического наблюдения до 20 лет (медиана: 14,1 года). Изучалось влияние использования антипсихотических препаратов в целом (то есть лечение любым антипсихотиком по сравнению с отсутствием антипсихотического лечения) и влияние отдельных антипсихотиков, анализировались следующие исходы: госпитализация в связи с соматическим и сердечно-сосудистым заболеванием, смерть от всех причин, в том числе в результате сердечно-сосудистых заболеваний и суицида. С целью устранения систематических ошибок отбора анализ госпитализаций проводился на основании данных на уровне одного лица путем сравнения у одного и того же индивидуума периодов, когда антипсихотики применялись и не применялись, с помощью стратифицированной модели Кокса. Оценка смертности проводилась на основании сопоставления данных между пациентами с помощью традиционных мн...

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Вход / Регистрация

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